Yüklüyor......
17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAF(V600E) inhibitors in melanoma cells of different genetic subtypes
Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17-aminogeldanamycin more potently activated caspase-3/7 in BRAF(V600E) melanoma cells than geldanamycin, another inhibitor of heat shock protei...
Kaydedildi:
| Yayımlandı: | Apoptosis |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Springer US
2019
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6598962/ https://ncbi.nlm.nih.gov/pubmed/30989459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-019-01542-y |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|