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Hydrogels Embedded With Melittin and Tobramycin Are Effective Against Pseudomonas aeruginosa Biofilms in an Animal Wound Model

We demonstrate that the antimicrobial peptide, melittin, is effective alone and in combination with the aminoglycosides tobramycin to kill Pseudomonas aeruginosa growing as biofilms both in vitro and in vivo. Melittin and tobramycin show enhanced in vitro activity in combination at micromolar concen...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Main Authors: Maiden, Michael M., Zachos, Mitchell P., Waters, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598697/
https://ncbi.nlm.nih.gov/pubmed/31293530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.01348
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