Vibrio vulnificus RtxA1 cytotoxin targets filamin A to regulate PAK1- and MAPK-dependent cytoskeleton reorganization and cell death

Cytoskeletal rearrangement and acute cytotoxicity occur in Vibrio vulnificus-infected host cells. RtxA1 toxin, a multifunctional autoprocessing repeats-in-toxin (MARTX), is essential for the pathogenesis of V. vulnificus and the programmed necrotic cell death. In this study, HeLa cells expressing Rt...

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Publicado en:Emerg Microbes Infect
Autores principales: Guo, Rui Hong, Im, Young Jun, Shin, Soo Im, Jeong, Kwangjoon, Rhee, Joon Haeng, Kim, Young Ran
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598492/
https://ncbi.nlm.nih.gov/pubmed/31237474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2019.1632153
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