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Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer’s Disease via Peroxisome Proliferator-Activated Receptor α

Deposition of extracellular senile plaques containing amyloid-β is one of the major neuropathological characteristics of Alzheimer’s disease (AD). Therefore, targeting amyloid-β dyshomeostasis is an important therapeutic strategy for treatment of AD. In this study, we demonstrate that gemfibrozil, a...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis Rep
Main Authors: Chandra, Sujyoti, Pahan, Kalipada
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597963/
https://ncbi.nlm.nih.gov/pubmed/31259309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ADR-190104
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