USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis

Hyperactivation of the canonical Wnt-signaling pathway is a prominent feature of a number of human malignancies. Transcriptional activation of this signaling cascade depends on the formation of the β-catenin–B-cell CLL/lymphoma 9 (BCL9)–pygopus (PYGO) family plant homeodomain finger 1 complex, yet h...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Shang, Zesen, Zhao, Jiao, Zhang, Qi, Cao, Cheng, Tian, Shanshan, Zhang, Kai, Liu, Ling, Shi, Lei, Yu, Na, Yang, Shangda
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597819/
https://ncbi.nlm.nih.gov/pubmed/31073027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007655
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