A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice

Inhibition of angiotensin-converting enzyme (ACE) is a strategy used worldwide for managing hypertension. In addition to converting angiotensin I to angiotensin II, ACE also converts neurotoxic β-amyloid protein 42 (Aβ42) to Aβ40. Because of its neurotoxicity, Aβ42 is believed to play a causative ro...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Liu, Shuyu, Ando, Fujiko, Fujita, Yu, Liu, Junjun, Maeda, Tomoji, Shen, Xuefeng, Kikuchi, Kota, Matsumoto, Aoi, Yokomori, Mirai, Tanabe-Fujimura, Chiaki, Shimokata, Hiroshi, Michikawa, Makoto, Komano, Hiroto, Zou, Kun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597817/
https://ncbi.nlm.nih.gov/pubmed/31072831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006420
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