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Upregulated Claudin-1 Expression Promotes Colitis-associated Cancer by promoting β-Catenin phosphorylation and activation in Notch/p-AKT Dependent Manner
In IBD patients, integration between a hyper-activated immune system and epithelial cell plasticity underlies colon cancer development. However, molecular regulation of such a circuity remains undefined. Claudin-1(Cld-1), a tight-junction integral protein deregulation alters colonic epithelial cell...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6597297/ https://ncbi.nlm.nih.gov/pubmed/30971761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0795-5 |
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