The Role of Ca(V)2.1 Channel Facilitation in Synaptic Facilitation

Activation of Ca(V)2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated Ca(V)2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that,...

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Publicado en:Cell Rep
Autores principales: Weyrer, Christopher, Turecek, Josef, Niday, Zachary, Liu, Pin W., Nanou, Evanthia, Catterall, William A., Bean, Bruce P., Regehr, Wade G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597251/
https://ncbi.nlm.nih.gov/pubmed/30811980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.114
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