Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined. Here, we show that loss of Shh results from hypermethylation of the CpG shore of the Shh gene, and tha...

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Vydáno v:eLife
Hlavní autoři: Kim, SungEun, Kim, Yubin, Kong, JungHo, Kim, Eunjee, Choi, Jae Hyeok, Yuk, Hyeong Dong, Lee, HyeSun, Kim, Hwa-Ryeon, Lee, Kyoung-Hwa, Kang, Minyong, Roe, Jae-Seok, Moon, Kyung Chul, Kim, Sanguk, Ku, Ja Hyeon, Shin, Kunyoo
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597241/
https://ncbi.nlm.nih.gov/pubmed/31036156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43024
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