Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined. Here, we show that loss of Shh results from hypermethylation of the CpG shore of the Shh gene, and tha...

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書目詳細資料
發表在:eLife
Main Authors: Kim, SungEun, Kim, Yubin, Kong, JungHo, Kim, Eunjee, Choi, Jae Hyeok, Yuk, Hyeong Dong, Lee, HyeSun, Kim, Hwa-Ryeon, Lee, Kyoung-Hwa, Kang, Minyong, Roe, Jae-Seok, Moon, Kyung Chul, Kim, Sanguk, Ku, Ja Hyeon, Shin, Kunyoo
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2019
主題:
Cancer Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597241/
https://ncbi.nlm.nih.gov/pubmed/31036156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43024
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