Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined. Here, we show that loss of Shh results from hypermethylation of the CpG shore of the Shh gene, and tha...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kim, SungEun, Kim, Yubin, Kong, JungHo, Kim, Eunjee, Choi, Jae Hyeok, Yuk, Hyeong Dong, Lee, HyeSun, Kim, Hwa-Ryeon, Lee, Kyoung-Hwa, Kang, Minyong, Roe, Jae-Seok, Moon, Kyung Chul, Kim, Sanguk, Ku, Ja Hyeon, Shin, Kunyoo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597241/
https://ncbi.nlm.nih.gov/pubmed/31036156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43024
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