Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease

Impaired intestinal epithelial barrier (IEB) function with loss of desmosomal junctional protein desmoglein 2 (DSG2) is a hallmark in the pathogenesis of inflammatory bowel disease (IBD). While previous studies have reported that glial cell line–derived neurotrophic factor (GDNF) promotes IEB functi...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Meir, Michael, Burkard, Natalie, Ungewiß, Hanna, Diefenbacher, Markus, Flemming, Sven, Kannapin, Felix, Germer, Christoph-Thomas, Schweinlin, Matthias, Metzger, Marco, Waschke, Jens, Schlegel, Nicolas
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597228/
https://ncbi.nlm.nih.gov/pubmed/31205031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120261
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