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Elevation of plasma tRNA fragments precedes seizures in human epilepsy

Transfer RNAs (tRNAs) are a major class of noncoding RNA. Stress-induced cleavage of tRNA is highly conserved and results in tRNA fragments. Here, we found that specific tRNA fragments in plasma are associated with epilepsy. Small RNA-Seq of plasma samples collected during video EEG monitoring of pa...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Hogg, Marion C., Raoof, Rana, El Naggar, Hany, Monsefi, Naser, Delanty, Norman, O’Brien, Donncha F., Bauer, Sebastian, Rosenow, Felix, Henshall, David C., Prehn, Jochen H.M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597227/
https://ncbi.nlm.nih.gov/pubmed/31039137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126346
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