Ablation of TFR1 in Purkinje Cells Inhibits mGlu1 Trafficking and Impairs Motor Coordination, But Not Autistic-Like Behaviors

Group 1 metabotropic glutamate receptors (mGlu1/5s) are critical to synapse formation and participate in synaptic LTP and LTD in the brain. mGlu1/5 signaling alterations have been documented in cognitive impairment, neurodegenerative disorders, and psychiatric diseases, but underlying mechanisms for...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Zhou, Jia-Huan, Wang, Xin-Tai, Zhou, Liang, Zhou, Lin, Xu, Fang-Xiao, Su, Li-Da, Wang, Hao, Jia, Fan, Xu, Fu-Qiang, Chen, Gui-Quan, De Zeeuw, Chris I., Shen, Ying
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596749/
https://ncbi.nlm.nih.gov/pubmed/29054881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1223-17.2017
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