Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity

Glutamate-mediated excitotoxicity induces neuronal death by altering various intracellular signaling pathways and is implicated as a common pathogenic pathway in many neurodegenerative diseases. In the case of motor neuron disease, there is significant evidence to suggest that the overactivation of...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Sugiyama, Kaori, Aida, Tomomi, Nomura, Masatoshi, Takayanagi, Ryoichi, Zeilhofer, Hanns U., Tanaka, Kohichi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596668/
https://ncbi.nlm.nih.gov/pubmed/28821644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0730-17.2017
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