Inhibition of IL-1β Signaling Normalizes NMDA-Dependent Neurotransmission and Reduces Seizure Susceptibility in a Mouse Model of Creutzfeldt–Jakob Disease

Creutzfeldt–Jakob disease (CJD) is a neurodegenerative disorder caused by prion protein (PrP) misfolding, clinically recognized by cognitive and motor deficits, electroencephalographic abnormalities, and seizures. Its neurophysiological bases are not known. To assess the potential involvement of NMD...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Bertani, Ilaria, Iori, Valentina, Trusel, Massimo, Maroso, Mattia, Foray, Claudia, Mantovani, Susanna, Tonini, Raffaella, Vezzani, Annamaria, Chiesa, Roberto
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596629/
https://ncbi.nlm.nih.gov/pubmed/28924012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1301-17.2017
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