Downregulation of RBO-PI4KIIIα Facilitates Aβ(42) Secretion and Ameliorates Neural Deficits in Aβ(42)-Expressing Drosophila

Phosphoinositides and their metabolizing enzymes are involved in Aβ(42) metabolism and Alzheimer's disease pathogenesis. In yeast and mammals, Eighty-five requiring 3 (EFR3), whose Drosophila homolog is Rolling Blackout (RBO), forms a plasma membrane-localized protein complex with phosphatidyli...

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Pubblicato in:J Neurosci
Autori principali: Zhang, Xiao, Wang, Wen-An, Jiang, Li-Xiang, Liu, Hai-Yan, Zhang, Bao-Zhu, Lim, Nastasia, Li, Qing-Yi, Huang, Fu-De
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596482/
https://ncbi.nlm.nih.gov/pubmed/28424219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3567-16.2017
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