Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

Excessive mitochondrial fission is a prominent early event and contributes to mitochondrial dysfunction, synaptic failure, and neuronal cell death in the progression of Alzheimer's disease (AD). However, it remains to be determined whether inhibition of excessive mitochondrial fission is benefi...

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Pubblicato in:J Neurosci
Autori principali: Baek, Seung Hyun, Park, So Jung, Jeong, Jae In, Kim, Sung Hyun, Han, Jihoon, Kyung, Jae Won, Baik, Sang-Ha, Choi, Yuri, Choi, Bo Youn, Park, Jin Su, Bahn, Gahee, Shin, Ji Hyun, Jo, Doo Sin, Lee, Joo-Yong, Jang, Choon-Gon, Arumugam, Thiruma V., Kim, Jongpil, Han, Jeung-Whan, Koh, Jae-Young, Cho, Dong-Hyung, Jo, Dong-Gyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596467/
https://ncbi.nlm.nih.gov/pubmed/28432138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2385-16.2017
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