A MedChem toolbox for cereblon-directed PROTACs

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Steinebach, Christian, Sosič, Izidor, Lindner, Stefanie, Bricelj, Aleša, Kohl, Franziska, Ng, Yuen Lam Dora, Monschke, Marius, Wagner, Karl G., Krönke, Jan, Gütschow, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596386/
https://ncbi.nlm.nih.gov/pubmed/31304001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00185a
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