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A MedChem toolbox for cereblon-directed PROTACs
A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of...
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| Veröffentlicht in: | Medchemcomm |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6596386/ https://ncbi.nlm.nih.gov/pubmed/31304001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00185a |
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