Mouse ER+/PIK3CA(H1047R) breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents

Estrogen dependence is major driver of ER + breast cancer, which is associated with PI3K mutation. PI3K inhibition (PI3Ki) can restore dependence on ER signaling for some hormone therapy-resistant ER + breast cancers, but is ineffective in others. Here we show that short-term supplementation with es...

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Publicado en:Oncogene
Main Authors: Stratikopoulos, Elias E., Kiess, Nicole, Szabolcs, Matthias, Pegno, Sarah, Kakit, Cheung, Wu, Xuewei, Poulikakos, Poulikos I., Cheung, Pamela, Schmidt, Hank, Parsons, Ramon
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596308/
https://ncbi.nlm.nih.gov/pubmed/30076411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0436-4
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