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Separation of β-Amyloid Tryptic Peptide Species with Isomerized and Racemized L-Aspartic Residues with Ion Mobility in Structures for Lossless Ion Manipulations

Accumulation of β-amyloid (Aβ) is one of the hallmarks of Alzheimer’s disease. The deposition of β-amyloid plaques is likely to start years in advance of manifestation of clinical symptoms, although the exact timing is unknown. Over the years, Aβ peptides undergo both post-translational modification...

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Publicado en:Anal Chem
Main Authors: Nagy, Gabe, Kedia, Komal, Attah, Isaac K., Garimella, Sandilya V. B., Ibrahim, Yehia M., Petyuk, Vladislav A., Smith, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596305/
https://ncbi.nlm.nih.gov/pubmed/30816701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b04696
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