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Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4′-derivatives
Halogenation of a suitably protected netilmicin derivative enables preparation of 4′-chloro-, bromo-, and iodo derivatives of netilmicin after deprotection. Suzuki coupling of a protected 4′-bromo derivative with phenylboronic acid or butyltrifluoroborate affords the corresponding 4′-phenyl and 4′-b...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595968/ https://ncbi.nlm.nih.gov/pubmed/31303992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00153k |
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