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Stereoselective semi-synthesis of the neuroprotective natural product, serofendic acid

We have recently demonstrated a synthetic biology-enabled semi-synthesis of the potent neuroprotective compound, serofendic acid. An engineered bacterium produces ent-atis-16-en-19-oic acid, which has six of eight chiral carbons configured with the appropriate stereochemistry. Setting the configurat...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Perusse, Dimitri, Smanski, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595966/
https://ncbi.nlm.nih.gov/pubmed/31303993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00145j
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