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Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies

BACKGROUND: Abnormally activated mechanistic target of rapamycin (mTOR) pathway has been reported in several model animals with inherited metabolic myopathies (IMMs). However, the profiles of mTOR pathway in skeletal muscles from patients are still unknown. This study aimed to analyze the activity o...

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Detalhes bibliográficos
Publicado no:Chin Med J (Engl)
Main Authors: Lyu, Jing-Wei, Xu, Xue-Bi, Ji, Kun-Qian, Zhang, Na, Sun, Yuan, Zhao, Dan-Dan, Zhao, Yu-Ying, Yan, Chuan-Zhu
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595864/
https://ncbi.nlm.nih.gov/pubmed/30897595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CM9.0000000000000144
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