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Catalytic, Enantioselective α-Alkylation of Azlactones with Non-Conjugated Alkenes via Directed Nucleopalladation

A palladium(II)-catalyzed enantioselective α-alkylation of azlactones with non-conjugated alkenes is described. The reaction employs a chiral BINOL-derived phosphoric acid as the source of stereoinduction and a cleavable bidentate directing group appended to the alkene to control the regioselectivit...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Angew Chem Int Ed Engl
Prif Awduron: Nimmagadda, Sri Krishna, Liu, Mingyu, Karunananda, Malkanthi K., Gao, De-Wei, Apolinar, Omar, Chen, Jason S., Liu, Peng, Engle, Keary M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595491/
https://ncbi.nlm.nih.gov/pubmed/30729619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201814272
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