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Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers
AIMS: Vonoprazan, a new class of potassium‐competitive proton pump inhibitors has been found to attenuate the antiplatelet function of clopidogrel in a recent clinical study, despite weak in vitro activity against CYP2C19. To elucidate the mechanism of this interaction, the present study investigate...
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| Published in: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595331/ https://ncbi.nlm.nih.gov/pubmed/30845361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13914 |
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