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Effect of CYP3A inhibitors on the pharmacokinetics of pevonedistat in patients with advanced solid tumours
AIMS: This phase I study evaluated the effects of the moderate cytochrome P450 (CYP) 3A inhibitor fluconazole and the strong CYP3A/P‐glycoprotein (P‐gp) inhibitor itraconazole on the pharmacokinetics of the investigational neural precursor cell expressed, developmentally downregulated 8 (NEDD8)‐acti...
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| Pubblicato in: | Br J Clin Pharmacol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595297/ https://ncbi.nlm.nih.gov/pubmed/30845347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13915 |
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