Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus

In leptin-deficient ob/ob mice, obesity and diabetes are associated with abnormal development of neurocircuits in the hypothalamic arcuate nucleus (ARC)(1), a critical brain area for energy and glucose homeostasis(2,3). As this developmental defect can be remedied by systemic leptin administration,...

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Pubblicato in:Nat Metab
Autori principali: Mirzadeh, Zaman, Alonge, Kimberly M., Cabrales, Elaine, Herranz-Pérez, Vicente, Scarlett, Jarrad M., Brown, Jenny M., Hassouna, Rim, Matsen, Miles E., Nguyen, Hong T., Garcia-Verdugo, Jose Manuel, Zeltser, Lori M., Schwartz, Michael W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594569/
https://ncbi.nlm.nih.gov/pubmed/31245789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-018-0029-0
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