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Regorefenib induces extrinsic/intrinsic apoptosis and inhibits MAPK/NF‐κB‐modulated tumor progression in bladder cancer in vitro and in vivo

The aim of the present study is to investigate anticancer effect and mechanism of regorafenib in bladder cancer in vitro and in vivo. Human bladder cancer TSGH 8301 cells were treated with regorafenib, NF‐κB, AKT, or mitogen‐activated protein kinase (MAPK) inhibitors for different time. The changes...

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Bibliografiske detaljer
Udgivet i:Environ Toxicol
Main Authors: Chiang, Chih‐Hung, Chung, Jing‐Gung, Hsu, Fei‐Ting
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594039/
https://ncbi.nlm.nih.gov/pubmed/30801954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/tox.22734
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