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Process monitoring of virus‐like particle reassembly by diafiltration with UV/Vis spectroscopy and light scattering

Virus‐like particles (VLPs) have shown great potential as biopharmaceuticals in the market and in clinics. Nonenveloped, in vivo assembled VLPs are typically disassembled and reassembled in vitro to improve particle stability, homogeneity, and immunogenicity. At the industrial scale, cross‐flow filt...

詳細記述

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書誌詳細
出版年:Biotechnol Bioeng
主要な著者: Rüdt, Matthias, Vormittag, Philipp, Hillebrandt, Nils, Hubbuch, Jürgen
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593973/
https://ncbi.nlm.nih.gov/pubmed/30684365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26935
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