Resolvin D2 elevates cAMP to increase intracellular [Ca(2+)] and stimulate secretion from conjunctival goblet cells

Under physiologic conditions, conjunctival goblet cells (CGCs) secrete mucins into the tear film to preserve ocular surface homeostasis. Specialized proresolving mediators (SPMs), like resolvins (Rvs), regulate secretion from CGCs and actively terminate inflammation. The purpose of this study was to...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Botten, Nora, Hodges, Robin R., Li, Dayu, Bair, Jeffrey A., Shatos, Marie A., Utheim, Tor P., Serhan, Charles N., Dartt, Darlene A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593886/
https://ncbi.nlm.nih.gov/pubmed/31013438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802467R
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