Plasminogen activator inhibitor‐1 augments damage by impairing fibrinolysis after traumatic brain injury

OBJECTIVE: Plasminogen activator inhibitor‐1 (PAI‐1) is the key endogenous inhibitor of fibrinolysis, and enhances clot formation after injury. In traumatic brain injury, dysregulation of fibrinolysis may lead to sustained microthrombosis and accelerated lesion expansion. In the present study, we hy...

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Publicado en:Ann Neurol
Main Authors: Griemert, Eva‐Verena, Schwarzmaier, Susanne M., Hummel, Regina, Gölz, Christina, Yang, Dong, Neuhaus, Winfried, Burek, Malgorzata, Förster, Carola Y., Petkovic, Ivan, Trabold, Raimund, Plesnila, Nikolaus, Engelhard, Kristin, Schäfer, Michael K., Thal, Serge C.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Ltd 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593843/
https://ncbi.nlm.nih.gov/pubmed/30843275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25458
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