Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models

Bullous pemphigoid (BP), the most common autoimmune blistering disease, is induced by autoantibodies to type XVII collagen (COL17). Previous studies demonstrated that COL17 harbors several epitopes targeted by autoreactive T and B cells and that the target epitopes change sequentially during the dis...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Ujiie, Hideyuki, Yoshimoto, Norihiro, Natsuga, Ken, Muramatsu, Ken, Iwata, Hiroaki, Nishie, Wataru, Shimizu, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593113/
https://ncbi.nlm.nih.gov/pubmed/31275329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01410
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