Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models

Bullous pemphigoid (BP), the most common autoimmune blistering disease, is induced by autoantibodies to type XVII collagen (COL17). Previous studies demonstrated that COL17 harbors several epitopes targeted by autoreactive T and B cells and that the target epitopes change sequentially during the dis...

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Библиографические подробности
Опубликовано в: :Front Immunol
Главные авторы: Ujiie, Hideyuki, Yoshimoto, Norihiro, Natsuga, Ken, Muramatsu, Ken, Iwata, Hiroaki, Nishie, Wataru, Shimizu, Hiroshi
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2019
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593113/
https://ncbi.nlm.nih.gov/pubmed/31275329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01410
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