Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models

Bullous pemphigoid (BP), the most common autoimmune blistering disease, is induced by autoantibodies to type XVII collagen (COL17). Previous studies demonstrated that COL17 harbors several epitopes targeted by autoreactive T and B cells and that the target epitopes change sequentially during the dis...

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Vydáno v:Front Immunol
Hlavní autoři: Ujiie, Hideyuki, Yoshimoto, Norihiro, Natsuga, Ken, Muramatsu, Ken, Iwata, Hiroaki, Nishie, Wataru, Shimizu, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593113/
https://ncbi.nlm.nih.gov/pubmed/31275329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01410
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