Design, synthesis, and biological evaluation of polyphenols with 4,6-diphenylpyrimidin-2-amine derivatives for inhibition of Aurora kinase A

BACKGROUND: Several 4,6-diarylpyrimidin-2-amine derivatives show anticancer properties. However, their mode of action is not fully characterized. To develop potent anticancer chemotherapeutic agents, we designed and synthesized 25 4,6-diphenylpyrimidin-2-amine derivatives containing a guanidine moie...

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Veröffentlicht in:Daru
Hauptverfasser: Lee, Young Han, Park, Jihyun, Ahn, Seunghyun, Lee, Youngshim, Lee, Junho, Shin, Soon Young, Koh, Dongsoo, Lim, Yoongho
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592983/
https://ncbi.nlm.nih.gov/pubmed/31154600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40199-019-00272-5
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