Advancing the Therapeutic Potential of Indoleamides for Tuberculosis

Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of Mycobacterium tuberculosis. In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Lun, Shichun, Tasneen, Rokeya, Chaira, Tridib, Stec, Jozef, Onajole, Oluseye K., Yang, Tian J., Cooper, Christopher B., Mdluli, Khisi, Converse, Paul J., Nuermberger, Eric L., Raj, V. Samuel, Kozikowski, Alan, Bishai, William R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2019
Pynciau:
Experimental Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591635/
https://ncbi.nlm.nih.gov/pubmed/31010860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00343-19
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg