Advancing the Therapeutic Potential of Indoleamides for Tuberculosis

Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of Mycobacterium tuberculosis. In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Lun, Shichun, Tasneen, Rokeya, Chaira, Tridib, Stec, Jozef, Onajole, Oluseye K., Yang, Tian J., Cooper, Christopher B., Mdluli, Khisi, Converse, Paul J., Nuermberger, Eric L., Raj, V. Samuel, Kozikowski, Alan, Bishai, William R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591635/
https://ncbi.nlm.nih.gov/pubmed/31010860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00343-19
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