Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Aspergillus fumigatus Into Type II Human Pneumocyte Cells

Aspergillus fumigatus is able to internalize into lung epithelial cells to escape from immune attack for further dissemination. We previously reported that gliotoxin, a major mycotoxin of A. fumigatus, promotes this internalization; however, the mechanism remained unclear. Here, we report that gliot...

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Udgivet i:Front Microbiol
Main Authors: Zhang, Changjian, Chen, Fangyan, Liu, Xiaoyu, Han, Xuelin, Hu, Yingsong, Su, Xueting, Chen, Yong, Sun, Yansong, Han, Li
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591310/
https://ncbi.nlm.nih.gov/pubmed/31275272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.01345
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