Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus

Through some specific amino acid residues, cofilin, a ubiquitous actin depolymerization factor, can significantly affect mitochondrial function related to drug resistance and apoptosis in Saccharomyces cerevisiae; however, this modulation in a major fungal pathogen, Aspergillus fumigatus, was still...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Lu, Zhongyi, Jia, Xiaodong, Chen, Yong, Han, Xuelin, Chen, Fangyan, Tian, Shuguang, Su, Xueting, Li, Zongwei, Zhao, Jingya, Zhang, Xi, Hu, Mandong, Huang, Liuyu, Han, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923094/
https://ncbi.nlm.nih.gov/pubmed/29483117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01659-17
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