Platelet factor 4-containing immune complexes induce platelet activation followed by calpain-dependent platelet death

Heparin-induced thrombocytopenia (HIT) is a complication of heparin therapy sometimes associated with thrombosis. The hallmark of HIT is antibodies to the heparin/platelet factor 4 (PF4) complex that cause thrombocytopenia and thrombosis through platelet activation. Despite the clinical importance,...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Death Discov
Autori principali: Nevzorova, Tatiana A., Mordakhanova, Elmira R., Daminova, Amina G., Ponomareva, Anastasia A., Andrianova, Izabella A., Le Minh, Giang, Rauova, Lubica, Litvinov, Rustem I., Weisel, John W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591288/
https://ncbi.nlm.nih.gov/pubmed/31263574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-019-0188-0
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi