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Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation
A unique bifunctional enzyme, isocitrate dehydrogenase kinase/phosphatase (AceK) regulates isocitrate dehydrogenase (IDH) by phosphorylation and dephosphorylation in response to nutrient availability. Herein we report the crystal structure of AceK in complex with ADP and Mn(2+) ions. Although the ov...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591243/ https://ncbi.nlm.nih.gov/pubmed/31235769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45704-z |
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