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Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK

The switch between the Krebs cycle and the glyoxylate bypass is controlled by isocitrate dehydrogenase kinase/phosphatase (AceK). AceK, a bifunctional enzyme, phosphorylates and dephosphorylates isocitrate dehydrogenase (IDH) with its unique active site that harbours both the kinase and ATP/ADP-depe...

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Bibliografiske detaljer
Main Authors: Zheng, Jimin, Yates, Susan P., Jia, Zongchao
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415836/
https://ncbi.nlm.nih.gov/pubmed/22889914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0426
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