Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell receptors (BCRs) are gathered into microclusters that recruit signaling enzymes. These microclusters then move centripetally and coalesce into the central supramolecular activation cluster of an immune synapse...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Bolger-Munro, Madison, Choi, Kate, Scurll, Joshua M, Abraham, Libin, Chappell, Rhys S, Sheen, Duke, Dang-Lawson, May, Wu, Xufeng, Priatel, John J, Coombs, Daniel, Hammer, John A, Gold, Michael R
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591008/
https://ncbi.nlm.nih.gov/pubmed/31157616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44574
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