Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering

In cellular immunotherapies, natural killer (NK) cells often demonstrate potent antitumor effects in high-risk cancer patients. But Good Manufacturing Practice (GMP)-compliant manufacturing of clinical-grade NK cells in high numbers for patient treatment is still a challenge. Therefore, new protocol...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther Methods
Main Authors: Oberschmidt, Olaf, Morgan, Michael, Huppert, Volker, Kessler, Joerg, Gardlowski, Tanja, Matthies, Nadine, Aleksandrova, Krasimira, Arseniev, Lubomir, Schambach, Axel, Koehl, Ulrike, Kloess, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590729/
https://ncbi.nlm.nih.gov/pubmed/30997855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2019.039
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