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ERBB3/HER3 and ERBB2/HER2 Duet in Mammary Development and Breast Cancer
ERBB3/HER3 is one of the four members of the epidermal growth factor receptor (ERBB) family. It is activated by binding to ligands Neuregulin-1 and Neuregulin-2. Since ERBB3 lacks intrinsic kinase activity, signal transduction occurs through formation of heterodimers with EGFR, ERBB2, and ERBB4. ERB...
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| Published in: | J Mammary Gland Biol Neoplasia |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6590701/ https://ncbi.nlm.nih.gov/pubmed/18454306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10911-008-9083-7 |
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