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Redox Chemistry in the Genome: Emergence of the [4Fe4S] Cofactor in DNA Repair and Replication
Many DNA-processing enzymes have been shown to contain a [4Fe4S] cluster, a common redox cofactor in biology. We find using DNA electrochemistry that binding of the DNA polyanion promotes a negative shift in [4Fe4S] cluster potential, which corresponds thermodynamically to ~ 500-fold increase in DNA...
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| Publicado en: | Annu Rev Biochem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6590699/ https://ncbi.nlm.nih.gov/pubmed/31220976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-013118-110644 |
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