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The [4Fe4S] Cluster of Human DNA Primase functions as a Redox Switch using DNA Charge Transport
DNA charge transport chemistry offers a means of long range, rapid redox signaling. Here we demonstrate that the [4Fe4S] cluster in human DNA primase can utilize this chemistry to coordinate the first steps of replication. Through DNA electrochemistry, we find that a change in oxidation state of the...
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| Publicado no: | Science |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5338353/ https://ncbi.nlm.nih.gov/pubmed/28232525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag1789 |
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