The [4Fe4S] Cluster of Human DNA Primase functions as a Redox Switch using DNA Charge Transport

DNA charge transport chemistry offers a means of long range, rapid redox signaling. Here we demonstrate that the [4Fe4S] cluster in human DNA primase can utilize this chemistry to coordinate the first steps of replication. Through DNA electrochemistry, we find that a change in oxidation state of the...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: O’Brien, Elizabeth, Holt, Marilyn E., Thompson, Matthew K., Salay, Lauren E., Ehlinger, Aaron C., Chazin, Walter J., Barton, Jacqueline K.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338353/
https://ncbi.nlm.nih.gov/pubmed/28232525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag1789
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