High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells

Concentrations of low-density lipoprotein (LDL) above 0.8 mg/ml have been associated with increased risk for cardiovascular diseases and impaired endothelial functionality. Here, we demonstrate that high concentrations of LDL (1 mg/ml) decreased NOS3 protein and RNA levels in primary human endotheli...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Gonnissen, Stefanie, Ptok, Johannes, Goy, Christine, Jander, Kirsten, Jakobs, Philipp, Eckermann, Olaf, Kaisers, Wolfgang, von Ameln, Florian, Timm, Jörg, Ale-Agha, Niloofar, Haendeler, Judith, Schaal, Heiner, Altschmied, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590621/
https://ncbi.nlm.nih.gov/pubmed/31281593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7976382
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