Optimization of Receptor Occupancy Assays in Mass Cytometry: Standardization Across Channels with QSC Beads

Receptor occupancy, the ratio between amount of drug bound and amount of total receptor on single cells, is a biomarker for treatment response to therapeutic monoclonal antibodies. Receptor occupancy is traditionally measured by flow cytometry. However, spectral overlap in flow cytometry limits the...

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Udgivet i:Cytometry A
Main Authors: Bringeland, Gerd Haga, Bader, Lucius, Blaser, Nello, Budzinski, Lisa, Schulz, Axel R., Mei, Henrik E., Myhr, Kjell‐Morten, Vedeler, Christian A., Gavasso, Sonia
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2019
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Technical Notes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590231/
https://ncbi.nlm.nih.gov/pubmed/30688025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.23723
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