Dupilumab reduces local type 2 pro‐inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis

BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a type 2‐mediated inflammatory disease associated with significant clinical, social, and economic burdens and high unmet therapeutic need. Dupilumab, a fully human monoclonal antibody targeting the interleukin‐4 receptor α (IL‐4Rα)...

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Vydáno v:Allergy
Hlavní autoři: Jonstam, Karin, Swanson, Brian N., Mannent, Leda P., Cardell, Lars‐Olaf, Tian, Nian, Wang, Ying, Zhang, Donghui, Fan, Chunpeng, Holtappels, Gabriele, Hamilton, Jennifer D., Grabher, Annette, Graham, Neil M. H., Pirozzi, Gianluca, Bachert, Claus
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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ORIGINAL ARTICLES
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590149/
https://ncbi.nlm.nih.gov/pubmed/30488542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.13685
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