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Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass

Children undergoing cardiac surgery often receive acetaminophen (paracetamol) as part of their postoperative pain treatment. To date, there is no information on the pharmacokinetics (PK) of acetaminophen in this special population, even though differences, as a result of altered hemodynamics and/or...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Mian, P., Valkenburg, A.J., Allegaert, K., Koch, B.C.P., Breatnach, C.V., Knibbe, C.A.J., Tibboel, D., Krekels, E.H.J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590134/
https://ncbi.nlm.nih.gov/pubmed/30633373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1373
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