Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass

Children undergoing cardiac surgery often receive acetaminophen (paracetamol) as part of their postoperative pain treatment. To date, there is no information on the pharmacokinetics (PK) of acetaminophen in this special population, even though differences, as a result of altered hemodynamics and/or...

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Опубликовано в: :J Clin Pharmacol
Главные авторы: Mian, P., Valkenburg, A.J., Allegaert, K., Koch, B.C.P., Breatnach, C.V., Knibbe, C.A.J., Tibboel, D., Krekels, E.H.J.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Pediatric Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590134/
https://ncbi.nlm.nih.gov/pubmed/30633373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1373
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